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KMID : 0613820080180040494
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Journal of Life Science
2008 Volume.18 No. 4 p.494 ~ p.502
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Immunotoxicity Study of Separated Antigen from Helicobacter pylori
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Bae Man-Jong
Park Chang-Ho
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Abstract
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The anaphylaxis shock reaction on the whole cells of H. pylori exhibited a symptom of slight illness for the first and second medication of causing antigen at an antigen concentration of WC (H) 60μg/100μ for WC (H) and no anaphylaxis shock symptom was observed at an antigen concentration of 20μg/100μ for WC (L). In the case of anaphylaxis shock reaction on the crude urease, no symptom was observed at an antigen concentration of 20μg/100μ for both urease (L) and urease (H). In the heterologous passive cutaneous anaphylaxis (PCA) test using a guinea pig-rat, no positive reaction was detected in all the medication groups of WC (H), WC (L), urease (H) and urease (L). In the skin sensitization test, it was observed that the best antigen concentration not causing skin disorder at each of 80μg/100μl, 40μg/100μl, 20μg/100μl, 20μg/100μl and was 40μg/100μ.
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KEYWORD
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Adjuvant, immunotoxicity, anaphylaxis, heterologous passive cutaneous anaphylaxis
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